R. Palla, C. Distratis, R. Cominotto
1987
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Abstract
Etozolin (E.) is an higly effective diuretic of thiazolidone group; it is well absorbed by G-I tract. E. undergoes first-pass metabolism to its 2-methilene-carboxilic acid Ozolinone wich displays a greater diuretic activity. By micropuncture studies E. site of action has been identified in the thick ascending limb of Henle’s loop (1).