Ren Yongqiang
2012
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Quality indicators
Journal
Medical Journal of the Chinese People's Armed Police Forces
Abstract
Objective To study the clinical therapeutic effect of paroxetine hydrochloride on refractory irritable bowel syndrome.Methods 124 patients with refractory irritable bowel syndrome,were randomly divided into conventional group(62 cases,receiving oral trimebutine maleate 0.1 g,3/d and bifidobacteria capsules 420 mg,3/d) and paroxetine group(62 cases,in addition to conventional treatment,oral paroxetine hydrochloride 20 mg,1/d).The course of treatment was 4 weeks for both groups.Before and after treatment,the Self-rating Anxiety Scale(SAS) and the Self-rating Depression Scale(SDS) were used for assessment.Symptom improvement and efficiency in the two groups after treatment were observed.Results In the paroxetine group,the total effective rate was 96.77% and 77.42% in the conventional group,with a significant difference(P0.01) between the two groups.The SAS and SDS scores after and before treatment in the paroxetine groups were significantly different(P0.01),SAS and SDS scores were not significantly different(P0.05) in the conventional group before and after treatment.The SAS and SDS scores before treatment were significantly different between patients with irritable bowel syndrome and normal group(P0.01).Conclusions Paroxetine hydrochloride in treatment of refractory irritable bowel syndrome is significantly efficient and can improve the patient's emotional state.