Li Wei-hu
2014
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Quality indicators
Journal
Chinese Journal of Hospital Pharmacy
Abstract
OBJECTIVE To study the clinical curative effect and safety of nalmefene hydrochloride in the treatment of severe neonatal asphyxia.METHODS 68 patients with severe neonatal asphyxia in our hospital from July,2010-January,2013 were randomly divided into the control group and the treatment group.There were 34 cases in each group.The control group accepted regular treatment while the treatment group accepted regular treatment and nalmefene hydrochloride.The clinical effects of the two groups were compared.RESULTS Consciousness disappearance time,abnormal primitive reflexes disappearing time and decreased muscle tone disappearance time of the treatment group were significantly less than those of the control group(P 0.05).After 3 days' treatment,serum level of NT-proBNP,PaO2,PaCO2,SaO2 and NABA score of the treatment group were statistically better than those of the control group(P0.05).The incidence of sequelae in 6 months after the discharge of the treatment group was statistically lower than that of the control group(P0.05).CONCLUSION Nalmefene hydrochloride has a significant effect and safety in the treatment of severe neonatal asphyxia,which is worth promoting.