Hormi Mecadon, M. R. Rohman, Iadeishisha Kharbangar
Jun 22, 2011
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0
Influential Citations
154
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3- c ]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l -proline (10 mol %) in water under mild reaction condition in excellent yields is established. A comparative study of l -proline with γ-alumina, basic alumina, and KF-alumina was also carried out. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.