Run-tao Li, Q. Wei, Xin Wang
Jul 11, 2017
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Journal
Synthesis
Abstract
Abstract An efficient cascade synthesis of ethyl 3-amino-5-oxoisoxazolidine-4-carboxylate derivatives from diethyl 2-(ethoxymethylene)malonate, different hydroxylamines and various amines is developed. This approach tolerates a wide range of amines affording highly functionalized isoxazolidine derivatives, which are expected to be important in organic synthesis and medicinal chemistry.