Naresh Vempala, A. Shree, Srikanth Reddy Narra
Sep 24, 2022
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Journal
Synlett
Abstract
A terse and efficient asymmetric synthesis of tert-butyl 2-(4R, 6R)-6-(2-aminoethyl)-2, 2-dimethyl-1, 3-dioxan-4-yl) acetate is presented, which is a key chiral chain precursor of atorvastatin. This was synthesized from commercially available, non-expensive starting material. The precursor was converted into atorvastatin calcium. The synthesis has the potential for scale-up and could be used to produce atorvastatin calcium on industrial scale.