Zehan Yin, Zhansheng Wang, Jing Xu
Mar 1, 2017
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Influential Citations
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Journal
Journal of Heterocyclic Chemistry
Abstract
This article describes an efficient approach for the synthesis of 5-amino-3-methyl-7-aryl-1,3-dihydroisobenzofuran-4,6-dicarbonitrile derivatives from the reaction of aromatic aldehyde, 2-methyltetrahydrofuran-3-one, and malononitrile under mild conditions. This is a simple and facile process to structure this important heterocyclic compounds. The other advantages of this approach are rapid reaction rate, high yield, and simple procedure. This article provided a good method for the synthesis of 1,3-dihydroisobenzofuran derivatives.