Xiang-Shan Wang, Jie-Xing Zhou, Ke-Fang Yang
Mar 4, 2010
Citations
0
Influential Citations
7
Citations
Journal
Synthetic Communications
Abstract
Three-component reaction of aromatic aldehyde, malononitrile, and 2-(1-(3-chlorophenyl)propylidene)malononitrile in aqueous media catalyzed by tetraethylbenzylammonium chloride (TEBAC) at 90 °C gave 2-amino-6-(3-chlorophenyl)-5-methyl-4-arylcyclohexa-1,5-diene-1,3,3-tricarbonitrile derivatives. The structure of 4e was further confirmed by x-ray diffraction. This three-component reaction had the advantages of green solvent, good yield, and operational simplicity.