V. A. Divate, Savita Dhongade-Desai
2014
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Journal
International Journal of Current Pharmaceutical Research
Abstract
A series of 7-amino-3-(substituted phenyl)-5-(substituted phenyl)-[1,2,4]triazolo [4,3a] pyrimidine-6-carbonitrile derivatives were synthesized from 4-amino-2-hydroxy (OR mercapto)-6-(substituted phenyl)-pyrimidine-5-carbonitrile, hydrazine hydrate and aromatic aldehydes. The derivatives were obtained in good yields by the microwave-assisted one-pot protocol in very short reaction time. The synthesized compounds were studied for QSAR by subjecting to a prediction of biological activities applying computer programme PASS. It is found that 7-Amino-3-(4-chlorophenyl)-5-(2,4-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile is a promising anticonvulsant agent; which can be synthesized by an efficient, promising, and green synthetic method with high yield.