Jamal Koubachi, S. E. Kazzouli, Sabine Berteina‐Raboin
Aug 1, 2008
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Journal
Synthesis
Abstract
In this paper, we present the synthesis of3-alkenylimidazo[1,2-a]pyridines in high to moderate yields by microwave direct palladium-catalyzed C-H alkenylation between bromoalkenes and imidazo[1,2-a]pyridines. The scope and limitation of the palladium(0)-catalyzed alkenylation method were investigated. Optimized conditions were successfully applied to a wide variety of imidazo[1,2-a]pyridine derivatives and bromoalkenes. The compatibility of the synthesis with the presence of a chloro substituent in the 6-position was investigated. The 6-chloroimidazo[1,2-a]pyridines ' were functionalized using Suzuki cross-coupling conditions to give polyfunctional compounds.