O. Lorthioir, Ryan D. R. Greenwood, Andrew S. Lister
Oct 29, 2020
Citations
0
Influential Citations
3
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In this work we describe the preparation of novel fused, spirocyclic and chiral triazolopiperazines. We have developed a practical, rapid and robust synthetic route to these scaffolds that allows control of regio- and stereochemistry. This method utilises mild conditions and uses widely available and diverse amino acids and amidines as starting materials. These complex unprecedented 5,6,7,8-tetrahydro- [1–2,4]triazolo[1,5-a]pyrazines represent attractive building blocks for drug discovery.