Xichen Lin, J. Busch-Petersen, Jianghe Deng
Nov 24, 2008
Citations
0
Influential Citations
8
Citations
Journal
Synlett
Abstract
Efficient and scalable chemical approaches to 3,5,7-trisubstituted1H-indazoles were developed and applied to the synthesis of 1,1-dimethylethyl4-[7-(aminocarbonyl)-5-bromo-1 H-indazol-3-yl]-1-piperidinecarboxylate,a key intermediate for 3,5,7-trisubstituted 1 H-indazole,which was identified as a potent IKK2 inhibitor. The sequence allowsfor a scalable preparation of the target compound in eight stepsand proceeds in 40% overall yield from readily availablestarting material.