K. Goswami, S. Vyas, K. P. Damor
2022
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Journal
RASAYAN Journal of Chemistry
Abstract
The work reports derivatives of 2-amino-4-(2-chloro-5-(4-substituted phenyl) pyridine-3-yl)-1-(4- substitutedphenyl)-7,7-disubstituted-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile Q(1-14) have been synthesized by the reaction of 5,5-disubstituted-1, 3-cyclohexanedione and 4- substituted aniline in the presence of ethanol and piperidine. The structure of synthesized compounds is characterized by spectroscopic methods suchas IR, 1H NMR, Mass Spectroscopy, and elemental analysis. The efficient novel derivativesQ(1-14) with different effective substituent (-CH3, -NO2, -OCH3 , -Br) was screened against antibacterial and antifungal effectively and showednotable action against tested microbes.