Chikao Hashimoto, Kazunobu Takeguchi, M. Kodomari
Jun 1, 2011
Citations
0
Influential Citations
7
Citations
Journal
Synlett
Abstract
The syntheses of N-protected dipeptide acids using alkaline earthmetal (Mg, Ca, and Ba) carboxylates of an amino acid in organicsolvents were investigated. It was found that amino acid calciumcarboxylates are the most effective among the carboxylates of theamino acids tested for coupling with active esters of Boc-Ala-OHin organic solvents. The coupling of Boc-Ala-ONp or Boc-Ala-ONSuwith amino acid calcium carboxylates in DMF gave the desired N-protecteddipeptide acids in high yields (92-100%).