Candice Menozzi Smarrito, Caroline Munari, F. Robert
Mar 10, 2008
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0
Influential Citations
18
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Journal
Organic & biomolecular chemistry
Abstract
A novel synthesis of 5-O-feruloylquinic acid, a polyphenolic compound found in coffee beans, and its methyl ester derivative has been optimized. The sequence involves 6 steps and is compatible with the preparation of potential human metabolites of these compounds. The key reaction is a Knoevenagel condensation of 4-hydroxy-3-methoxy-benzaldehyde and a malonate ester of quinic acid.