Afzal Shah, A. Ullah, A. Rauf
2013
Citations
0
Influential Citations
13
Citations
Journal
Journal of The Electrochemical Society
Abstract
Thedetailedelectrochemistryofabiologicallyactiveisoquinoline,2-benzoyl-7-methoxy-2,3-dihydroisoquinoline-4(1H)-one(IQN)wascarriedoutindifferentpHmediawiththeobjectiveofelucidatingitsredoxmechanism.Cyclicvoltammetrywasusedtodeterminepka, diffusion coefficient and heterogeneous electron transfer rate constant. The involvement of protons in redox mechanism wasconfirmedfromashiftinpeakpotentialasafunctionofpH.Differentialpulsevoltammetrywasusedtoverifythenumberofelectronsinvolvedintheredoxprocess.Thereversibilityoftheredoxprocesswasdecidedonthebasisoftheresultsobtainedfromsquarewavevoltammetry. The existence of IQN in keto and enol forms was evidenced by UV-Vis spectroscopy. The redox mechanism proposedon the basis of voltammetric and electronic absorption spectroscopic investigations was supported by theoretical calculations. Thesemechanisticpathwaysareexpectedtopresentakeyinunderstandingthehiddenroutesbywhichisoquinolinesexerttheirbiochemicalaction.© 2013 The Electrochemical Society. [DOI: 10.1149/2.063309jes] All rights reserved.Manuscript submitted May 23, 2013; revised manuscript received June 21, 2013. Published June 28, 2013.