P. W. Crawford, E. Carlos, J. C. Ellegood
1996
Citations
0
Influential Citations
36
Citations
Quality indicators
Journal
Electrochimica Acta
Abstract
Abstract The electrochemical reductions of 9 benzo[ b ]naphtho[2,3- d ]furan-6,11-dione derivatives in dimethylformamide were investigated. In the aprotic medium the quinones reduced in two successive one-electron steps. The influence of molecular structure on reduction potential is addressed. The reduction process involved a single irreversible two-electron process in the presence of a proton source, occurring via an ECE mechanism. A relationship is observed between reduction potential and reported inhibitory activity against various cancer cell lines. The hydroxyl substituted derivatives exhibit the most positive E 1 2 values and have generally more potent activities.