B. Uslu, S. Ozkan, Z. Şentürk
Jan 12, 2006
Citations
1
Influential Citations
51
Citations
Journal
Analytica Chimica Acta
Abstract
Abstract The electrochemical properties of valacyclovir, an antiviral drug, were investigated in pH range 1.8–12.0 by cyclic, differential pulse and square-wave voltammetry. The drug was irreversibly oxidized at a glassy carbon electrode in one or two oxidation steps, which are pH-dependent. For analytical purposes, a very resolved diffusion controlled voltammetric peak was obtained in Britton–Robinson buffer at pH 10.0 using differential pulse and square-wave modes. Limits of detection were 1.04 × 10 −7 and 4.60 × 10 −8 M for differential pulse and square-wave voltammetry, respectively. The applicability to direct assays of tablets, spiked human serum and simulated gastric fluid, was described.