M. Schwaninger, P. Ringleb, Ralph Winter
Mar 1, 1999
Citations
9
Influential Citations
167
Citations
Quality indicators
Journal
Epilepsia
Abstract
Summary: Purpose: Homocysteine is an experimental convulsant and an established risk factor in atherosclerosis. A nuritional deficiency of vitamin B6, vitamin B12, or folate leads to increased homocysteine plasma concentrations. During treatment with carbamazepine (CBZ), phenytoin, or phenobarbital, a deficiency in these vitamins is common. The objective of the study was to test the hypothesis that antiepileptic drug (AED) treatment is associated with increased homocysteine plasma concentrations.