H. Ragan, E. Autry, Taryn Bomersback
Jun 21, 2021
Citations
1
Influential Citations
14
Citations
Quality indicators
Journal
Pediatric Pulmonology
Abstract
Cystic fibrosis (CF)‐related liver disease (CFLD) manifests as a wide spectrum of hepatobiliary disease and can progress to need liver transplantation. Elexacaftor/tezacaftor/ivacaftor (elx/tez/iva) is a cystic fibrosis transmembrane conductance regulator modulator that has superior efficacy compared to previously approved modulators. Use of elx/tez/iva, should be approached with caution in individuals with CFLD or following liver transplantation due to possible increases in liver function tests (LFTs) and drug–drug interactions with several immunosuppressant medications.