1955
Citations
0
Influential Citations
8
Citations
Journal
Annals of the rheumatic diseases
Abstract
In the last 6 years cortisone acetate (hereafter designated "cortisone") has been widely used in the treatment of rheumatoid arthritis, but of the numerous studies made on a sufficiently wide scale, only two have made a controlled comparison over a prolonged period between this treatment and another. Both of these trials were carried out at a number of centres in Great Britain under the auspices of the Medical Research Council and the Nuffield Foundation. One dealt with the use of cortisone as an adjuvant to manipulation compared with tablets of aspirin, codeine, and phenacetin (Medical Research Council and Nuffield Foundation, 1954). The second trial compared cortisone with aspirin in the treatment of early cases of rheumatoid arthritis of less than 9 months' duration at the start of treatment (Medical Research Council and Nuffield Foundation, 1954b, 1955). Neither of these trials showed any striking advantage of cortisone over salicylate medication. These results coincided with the publication of the only controlled trial of hormones and aspirin in rheumatic fever (Joint Report by the Rheumatic Fever Working Party of the Medical Research Council of Great Britain and the American Council