Hongrui Zhang, Haifeng Li, Jijun Xue
Jan 7, 2014
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0
Influential Citations
14
Citations
Journal
Organic & biomolecular chemistry
Abstract
A novel formal asymmetric synthesis of (-)-triptonide and (-)-triptolide, featuring a new alternative access to their known key intermediate 4, has been achieved through two synthetic routes in 9 steps with 13.6% total yield and 10 steps with 18.5% overall yield, respectively. This synthesis is scalable and hence has high potential for application to further synthetic elaboration and biologic investigation on such natural products.