B. J. Ueberbacher, I. Osprian, S. Mayer
Apr 1, 2005
Citations
1
Influential Citations
17
Citations
Journal
European Journal of Organic Chemistry
Abstract
A chemoenzymatic, asymmetric total synthesis of the anti-biotic (R)-fridamycin E has been accomplished following a biocatalytic deracemization procotol. The key step comprises the construction of the chiral side-chain from a functionalized rac-2,2-disubstituted oxirane via a kinetic resolution/stereoinversion sequence without formation of the undesiredstereoisomer. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)