J. Pietruszka, Gemma Solduga
Dec 1, 2009
Citations
0
Influential Citations
23
Citations
Journal
European Journal of Organic Chemistry
Abstract
Cyclopropylamines are versatile intermediates and products both in organic synthesis in general and for active substances in particular. Although the synthesis of the corresponding enantiomerically pure cyclopropylboronic esters had been established previously, the C–B to C–N transformation was elusive. A detailed study directed towards the synthesis of several enantiomerically pure cyclopropylamines is disclosed; tranylcypromine [(1S,2R)-36] and the known belactosin A intermediate 43 were both obtained by use of trifluoroborates as key intermediates. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)