T. Upadhya, S. Gurunath, A. Sudalai
Jul 30, 1999
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Influential Citations
14
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Journal
Tetrahedron-asymmetry
Abstract
Abstract Dihydro-4,4-dimethyl-2(3 H )-furanone 6 , the key intermediate to ( R )-pantolactone 2 , has been synthesized in two steps via the radical cyclization of bromoether 5 . Silyl enol ether 7 , prepared from 6 , on Sharpless asymmetric dihydroxylation gave ( R )-pantolactone 2 in moderate yield and excellent enantioselectivity.