G. M. Irwin, G. J. Dodson, L. J. Ravin
Apr 1, 1970
Citations
0
Influential Citations
18
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Abstract A correlation has been shown to exist between the flow properties of clomacran phosphate powder blends and capsule fill weight variation when an automatic capsule-filling machine is used.A correlation of 0.96 was obtained for the capsule mixes tested.Weight variation of the finished capsules is also affected by lot-to-lot variability and concentration of clomacran phosphate.Granulation of the active ingredient overcomes most of the problems normally encountered and provides finished capsules of uniform weight.