G. Yadav, Omprakash V. Badure
Jun 18, 2008
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0
Influential Citations
5
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Journal
Organic Process Research & Development
Abstract
Monobenzyl ether of resorcinol, namely, 3-(phenylmethoxy)phenol is used as an intermediate for the synthesis of various chemically and biologically active molecules. The synthesis of 3-(phenylmethoxy)phenol can be accomplished by using phase transfer catalysis (PTC), either as liquid–liquid (L−L) or solid–liquid (S−L) PTC. Creation of a third phase in a biphasic reaction leads to several advantages in this type of reaction. A catalyst rich middle phase is formed between the other two phases wherein the main reaction takes place in the liquid–liquid−liquid (L−L−L) PTC and this offers a number of advantages over L−L PTC in terms of intensification of rate, higher selectivity and the possibility to reuse the catalyst. It is an excellent way for waste reduction and improving profitability. The catalyst rich phase is recovered and reused to up to six times with little impact to reactivity. This also helps in waste minimization which is a major theme of Green Chemistry. In the current work, synthesis of 3-(phen...