R. Ambaye, M. Indap, S. Naik
2004
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of Cancer Research and Clinical Oncology
Abstract
Summary(R,S)3-{N,N-[bis-(2-chloroethyl)]-amino}-1-(2′-methoxyphenyl)-pyrrolidine-2,5-dione hydrochloride (I) has shown antitumor activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites). The effect of (I), when co-administered with anticancer drugs, was studied in these murine tumours. Although co-administration of (I) with methotrexate showed a significant increase of the activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites), co-administration of (I) with 5-fluorouracil, mitomycin C, adriamycin or vincristine did not exhibit any enhancing, synergistic or additive effect in the activity of these drugs.