S. Quadri, G. Kledzik, J. Meites
Mar 1, 1974
Citations
1
Influential Citations
33
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary The effects of either ergocornine (EC), ovariectomy (Ovx), or high doses of estradiol benzoate (EB) alone, or combinations of EC and Ovx or EC and EB on growth of 7,12-dimethylbenz(a)anthracene-induced mammary cancers were investigated in female Sprague-Dawley rats. After the cancers reached at least 1 cm in their largest diameter, the rats were ovariectomized or were given daily injections of EC (0.2 mg/100 g body weight) or EB (20 µg/rat) or were treated with combinations of EC and Ovx or EC and EB. By the end of 3 weeks, the combined treatments reduced mammary tumor size and number to a greater degree than any single treatment. The greater effectiveness of the combined treatments is believed to be due to the more complete inhibition of prolactin release produced by EC, together with the loss of estrogen resulting from Ovx or to the peripheral interference with prolactin action by high doses of EB.