H. Tomosaka, S. Omata, K. Anzai
Aug 23, 1994
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Bioscience, biotechnology, and biochemistry
Abstract
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.