S. Sturelid, B. Kihlman
Feb 12, 2009
Citations
0
Influential Citations
28
Citations
Quality indicators
Journal
Hereditas
Abstract
In root tips of Vicia faba 5-hour post-treatments with 2.5 times 10-3 M caffeine increased the frequency of chromosomal aberrations independently of the temperature during the exposure to caffeine when the aberrations were produced by maleic hydrazide and by monofunctional alkylating agents. The post-treatments were equally effective when given 1 hour after as when given 6 hours after the exposure to the monofunctional agents. In contrast, the frequencies of aberrations produced by di- and trifunctional alkylating agents were enhanced by caffeine much more effectively at 25°C than at 10°C, and when the post-treatments were given 5 to 6 hours after than immediately after exposure. In Chinese hamster cells, 5-hour post-treatments with 2.0–2.5 times 10-3 M 8-chlorocaffeine increased the frequency of chromosomal aberrations produced by mono-, di- and trifunctional alkylating agents most effectively when given immediately after inducer treatments. Whereas the potentiating effect of 8-chlorocaffeine was independent of the temperature during exposure to 8-chlorocaffeine for the monofunctional alkylating agents, it was clearly dependent on temperature for the di- and trifunctional ones, being much stronger when the cells were exposed to 8-chlorocaffeine at 37°C than at 20°C.