M. Langat, N. Crouch, L. Pohjala
Sep 1, 2012
Citations
1
Influential Citations
25
Citations
Quality indicators
Journal
Phytochemistry Letters
Abstract
Abstract Two new ent -kauren-19-oic acid derivatives, ent -14 S* -hydroxykaur-16-en-19-oic acid and ent -14 S *,17-dihydroxykaur-15-en-19-oic acid together with eleven known compounds ent -kaur-16-en-19-oic acid, ent -kaur-16-en-19-al, ent -12β-hydroxykaur-16-en-19-oic acid, ent -12β-acetoxykaur-16-en-19-oic acid, 8 R ,13 R -epoxylabd-14-ene, eudesm-4(15)-ene-1β,6α-diol, (−)-7-epivaleran-4-one, germacra-4(15), 5 E ,10(14)-trien-9β-ol, acetyl aleuritolic acid, β-amyrin, and stigmasterol were isolated from the stem bark of Croton pseudopulchellus (Euphorbiaceae). Structures were determined using spectroscopic techniques. Ent -14 S *-hydroxykaur-16-en-19-oic acid, ent -kaur-16-en-19-oic acid, ent -12β-hydroxykaur-16-en-19-oic acid, ent -12β-acetoxykaur-16-en-19-oic acid and 8 R ,13 R -epoxylabd-14-ene were tested for their effects on Semliki Forest virus replication and for cytotoxicity against human liver tumour cells (Huh-7 strain) but were found to be inactive. Ent -kaur-16-en-19-oic acid, the major constituent, showed weak activity against the Plasmodium falciparum (CQS) D10 strain.