Wen-Wu Sun, N. Chen, Ting-Ting Wei
Jul 13, 2020
Citations
0
Influential Citations
5
Citations
Journal
The Journal of organic chemistry
Abstract
An environmentally friendly and highly regioselective C-3 dichlorination and C-2 oxidation of N-substituted indoles has been established by using NaCl as a chlorine source and H2O as an oxygen source. A series of 3,3-dichloro-2-oxindoles were obtained in moderate to excellent yields. The gram-scale synthesis and derivatization reaction were explored. The possible mechanism for this reaction was elucidated.