M. Mamaghani, Alireza Alizadehnia
Aug 1, 2002
Citations
1
Influential Citations
6
Citations
Journal
Journal of Chemical Research
Abstract
Racemic methyl 3-endo-acetylbicyclo[2.2.1]hept-5-ene-2-exo-carboxylate and methyl 3-exo-acetylbicyclo[2.2.1]hept-5-ene-2-endo-carboxylate were prepared (as a 1:1 mixture in 98% yield) from (E)-methyl 4-oxo-2-pentenoate, using Diels–Alder methodology. The mixture was separated chromatographically and resolved into the enantiomers by pig liver esterase (PLE) with low to high ee's (98%).