E. Brenna, C. Fuganti, F. Gatti
Nov 26, 2009
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Influential Citations
14
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Journal
Tetrahedron-asymmetry
Abstract
Abstract A new scaleable synthetic route to the title compounds has been developed. The reaction pathway is based on the α-chymotrypsin-catalysed hydrolysis of the racemic ethyl 2-ethoxy-3-( p -methoxyphenyl)propanoate or of the racemic ethyl 2-methoxy-3-( p -methoxyphenyl)propanoate to give the corresponding resolved ( S )-esters with excellent ee. The acids were easily separated from the ( S )-esters by a simple acid–base work-up. The overall yields of 1 and 2 were 16% and 17%, respectively.