Sun Chun-hua
2005
Citations
0
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Journal
The Chinese Journal of Clinical Pharmacology
Abstract
Ertapenem sodium(trade name Invanz TM , also designated as MK-826,L-749345) is structurally unique parenteral 1β-methyl carbapenem. It has a broad spectrum of antimicrobial activity, including common community -acquired Gram-positive and Gram-negative aerobic and anaerobic pathogens, and restricted activity again nosocomial pathogens such as Pseudomonas aeruginosa, Acinetobacter species, methicillin-resis-tant staphylococci and entercocci. Ertapenem demonstrates excellent activity against cephalosporin-resistant enteric organisms producing extended spectrum β-lactamasesa(ESBLS) or AmpC β-lactamasesa and excellent activity against Streptococcus pneumoniae. Its high level of protein bonding and serum half-life of 4 h allow it to be dosed once daily. Ertapenem may be administered intravenously or intramuscularly and has an excellent adverse reaction and tolerability profile.