Takeshi Takahashi
Nov 1, 1969
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Biotechnology and Bioengineering
Abstract
A brief review of the development of the research on erythorbic acid fermentation was presented. A previously proposed scheme of the acid biosynthesis has been proved to be correct. D‐glucono‐γ‐lactone dehydrogenase was purified to 50 fold and compared with other lactone dehydrogenases. For the purpose of commercial development, screening and mutagenie treatments of strains and studies on fundamental cultural conditions were carried out. Penicillium, but no other genera, was obtained as a producer. The experiments of ultraviolet irradiation and various cultural conditions were successful in elevating the yield of the acid over 40% in jar‐fermentor to glucose supplied. The continuous multibed extraction system of anion‐exchange resin was developed and a yield of 19.2% of the acid from fermentation broth was obtained.