E. G. Brain, A. K. Forrest, E. Hunt
Dec 25, 1989
Citations
0
Influential Citations
22
Citations
Quality indicators
Journal
The Journal of antibiotics
Abstract
Erythromycin A oxime 11,12-carbonate (5a) and its oxime ethers 5b approximately 5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and its 11,12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative organisms, in some cases being even more active than the carbonate 2.