N. Zhou, L. Hu, G. Zhou
2006
Citations
0
Influential Citations
2
Citations
Journal
Letters in Peptide Science
Abstract
The reactions of natural non-polar amino acids with phosphorus oxychloride were investigated. Some non-polar amino acids, such as L-Phe, L-Leu and L-Val were treated with phosphorus oxychloride, then quenched with water or some bioactive compounds (L-menthol, cinchonidine and benzylamine), and yielded the corresponding peptide and peptide conjugate libraries. ESI-MS/MS was used to study the products of the reaction and confirm the structure of the library. This paper reports a simple method to synthesize the homo-oligo-peptide libraries and peptide conjugated libraries.