P. Kerekes, A. Brossi, J. Flippen-Anderson
May 15, 1985
Citations
0
Influential Citations
13
Citations
Journal
Helvetica Chimica Acta
Abstract
1-O-Acetyl-1-O-demethylcolchicine, and acylated 1-O,2-O-didemethylthiocolchicines, in contrast to 2-O-acetyl-, 2-O,3-O-diacetyl- and 3-O-acetyl analogs, showed after standing in CHCl3 solution significant changes in optical rotation, a duplication of 1H-NMR signals, and the formation of new isomers on TLC. Solid-state X-ray diffraction of O-acetylated colchinoids and thio analogs, showed out of planar arrangements of the aromatic substituents, but the analysis could not help to explain the structures of the newly formed isomers in CHCl3 solution.