H. Blaser, Stephan Burkhardt, H. Kirner
Aug 1, 2003
Citations
0
Influential Citations
18
Citations
Journal
Synthesis
Abstract
Starting from ethyl 2,4-dioxo-4-phenylbutyrate, both enantiomers of six enantiomerically pure a-hydroxy and a-amino acid esters (homophenylalanine derivatives) were prepared on >100 g scale. The key step involves a Pt-cinchona catalyzed enantioselective hydrogenation followed by enrichment via crystallization. All derivatives are commercially available.