V. P. Kislyi, A. Laikhter, B. Ugrak
1994
Citations
0
Influential Citations
5
Citations
Journal
Russian Chemical Bulletin
Abstract
It was shown that ethyl 2-nitroacetoacetate is a synthetic precursor of ethoxycarbonylnitrile oxide as well as of isoxazole- and isoxazoline-3-carboxylic acids and their esters. The elimination of acetic acid from ethyl 2-nitroacetoacetate occurs in a mixture of acetic acid and acetic anhydride in the presence of strong mineral acids,e.g., H2SO4, at room temperature and gives isoxazolines in yields of up to 85–91 %.