Yanwen Fu, L. Hammarström, T. Miller
2001
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Journal
ChemInform
Abstract
The discovery of Cα, α-disubstituted amino acids (ααAAs) and their propensity to induce secondary structure even into short peptides has resulted in an increased interest in novel methods for their synthesis [1, 2]. Herein ethyl nitroacetate, a useful synthetic intermediate for a variety of biologically significant compounds [3], has been employed for the preparation of sterically hindered and polyfunctional ααAAs which are suitable for incorporation into peptides.