Johansson As, K. Johansson-Haque, S. Okret
Jul 1, 2008
Citations
1
Influential Citations
43
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
Endothelial cell activation plays a critical role in regulating leukocyte recruitment during inflammation and infection. Ethanol (EtOH) reduces host defence systems, including cell adhesion. However, well‐known side effects of EtOH limit its clinical use as an anti‐inflammatory drug. Instead, ethyl pyruvate (EtP) may represent a better alternative. Here, we compared effects of EtP and EtOH on neutrophil recruitment and activation of human umbilical vein endothelial cells (HUVECs).