H. Shimizu, D. Nagel, B. Tóth
Apr 15, 1974
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Influential Citations
16
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Journal
International Journal of Cancer
Abstract
The lifetime administration of 0.0125% ethylhydrazine hydrochloride in drinking water to randomly bred Swiss mice, beginning at 7 weeks of age, induced tumors of the lungs and blood vessels. Eighty‐eight percent of the treated females and 62% of the treated males developed lung tumors, whereas among the controls, the incidence was 21% in the females and 23% in the males. In addition, the incidence of blood‐vessel tumors rose from 5 to 60% in the females and from 6 to 16% in the males, as compared with the controls. The gross and light microscopic investigation of the tumors showed adenomas and adenocarcinomas of the lungs and angiomas and angiosarcomas of the blood vessels of characteristic appearance. This investigation proves for the first time the tumorigenicity of this chemical. The environmental significance of hydrazine derivatives is discussed in the light of the obtained results.