P. Canonne, D. Thibeault, G. Fytas
1986
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron
Abstract
Abstract Ozimes of 1-methyl and 1-phenyl-3(hydroxycyclopentyl)-2-atkanones were prepared in one step with high yeild, from 1 ,4-bis(bromomagnesio) butane and 5-isoxazolones in tetrahydrofuran. This reaction was found to be general and applicable to any hindered 5- isoxazolones providing a facile route for the synthesis of the corresponding spiroisoxazolines. The much larger yeilds of reduction product obtained with 1,5-bis (bromomagnesio)- pentane showed an important difference between five- and six membered annelation process.