G. Neville
Apr 15, 1972
Citations
0
Influential Citations
9
Citations
Journal
Canadian Journal of Chemistry
Abstract
1-Ethyl-1,6-dihydro-2,4-dimethoxy-5-methyl-6-oxopyrimidine (1a) and 1,5-diethyl-1,6-dihydro-2,4-dime-thoxy-6-oxopyrimidine (2a) are shown to be the correct positional isomers, respectively, for the major O,O-dimethyl derivatives isolated from the reaction products of 1-ethyl-5-methylbarbituric acid (1) and the new 1,5-diethylbarbituric acid (2) with excess diazomethane. In addition to the above compounds, the behavior of 2,4-dimethoxypyrimidine (3), 4,6-dimethoxypyrimidine (4), 2,4,6-trimethoxypyrimidine (5), and 6-chloro-2,4-dimethoxypyrimidine (6) were studied by p.m.r. spectrometry in various solvents. The relatively new shift reagent, Eu(fod)3 was used in these studies because of its affinity for weak electron donors such as ethers.