K. Rickels
1990
Citations
0
Influential Citations
3
Citations
Journal
Psychopharmacology series
Abstract
During recent years, many experimental compounds have entered the clinical research arena. The hope has been to find effective anxiolytics and antidepressants, with clinical efficacy at least as great as such standards as diazepam for anxiety and imipramine or amitriptyline for depression, but at the same time with a milder adverse event profile. For anxiolytics, this would translate primarily into producing less sedation and no dependency-producing properties, and for antidepressants primarily an absence or reduction of anticholinergic properties, excessive sedation, orthostatic hypertension, and cardiac toxicity.