M. A. El-Moneim, I. M. El‐Deen, W. A. El-Fattah
Oct 1, 2011
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Journal
Indian journal of applied research
Abstract
4-Benzylidene-2-(p-chlorophenyl)-4H-oxazol-5-one (2) was prepared via cylcocondensation of N-(p-chlo- robenzoyl) glycine with benzaldehyde in presence of fused sodium acetate and acetic anhydride. Condensation of 2 with semicarbazide hydrochloride in presence of fused sodium acetate afforded the corresponding 3,5-disubitut- ed-2-(aminocarbonyl)-1,2,4-triazine-6-one (3). Acetylation of 3 with acetic anhydride yielded the monoacetyl and diacetyl derivatives (4 and 5). Methyl α -(p-chlorobenzoyl) amino- β -phenyl acrylate (6) was synthesized via the reaction of 2 with triethylamine in methanol. 5,6-disubstituted-4-hydroxypyrimidine-2-thiole (7) was obtained via cyclocondensation of ester (6) with thiourea in presence of anhydrous potassium carbonate. Synthesized compounds were characterized by EI-MS and NMR spectroscopy. The biological activity studies of triazines and pyrimidine-2-thiole were carried out against antioxidant and antitumor activities. GC/MS with (chemical ionization) En-gine Thermospray ionization 200°C and the emission current = 100mA. Microanalyses conducted