J. Reinarz, C. Kier, J. C. Guckian
Oct 1, 1973
Citations
0
Influential Citations
20
Citations
Quality indicators
Journal
The Journal of infectious diseases
Abstract
Seven patients with bacterial endocarditis and two patients with bacteremia were treated with cefazolin, with excellent bacteriologic and good clinical response. Dosage of cefazolin was 4-12 g daily. Large doses of cefazolin (12 g/day) were tolerated well by these patients without evidence of hematotoxicity, hepatotoxicity, or nephrotoxicity. Cefazolin is an effective antimicrobial agent for treatment of serious infections caused by susceptible gram-positive organisms. Cefazolin is a derivative of 7-aminocephalosporanic acid, which is bactericidal for Staphylococcus, group A Streptococcus, Diplococcus pneumoniae, several members of the order Enterobacteriaceae, particularly E. coli and Klebsiella pneumoniae, and certain Shigella and Salmonella species [1-4]. Cefazolin may be administered iv or im. It appears to be less painful than cephalothin when administered im, and preliminary results suggest less nephrotoxicity than that reported for cephaloridine [5-11]. The present study is a report of cefazolin therapy in seven patients with bacterial endocarditis and two with pneumococcal bacteremia.